BRAF belongs to the upstream portion of the MAPK pathway, which is involved in cell proliferation and survival.When mutations occur in BRAF, downstream MEK and GREY CLAY ERK are phosphorylated irrespective of RAS, resulting in melanoma-like cancer.Over the years, small molecules targeting BRAFV600E have been discovered to be very effective melanoma

Since the new millennium, living in historic cities has become extremely popular in the Netherlands.As a consequence, historic environments are being adapted to meet modern living standards.Houses are constantly subjected to development, restoration and renovation.Although most projects are carried out with great care and strive to preserve and res

Global warming, human activities, and increased water demand have led to a decrease in the resilience of the Coaxial Adaptor environment.Their effects in dry climates like Iran lead to the reduction of surface water and a water table drop.To evaluate the adaptation strategy for water resources with climate change, the Cham Anjir watershed was selec

Fred A English,1 Louise C Kenny,1 Fergus P McCarthy1,2 1Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland; 2Women’s Health Academic Centre, King's Health Partners, St Thomas' Hospital, London, UK Abstract: Preeclampsia, a hypertensive d

Kevin Nugent,1 Wallace Smart2,3 1Kinark Child and Family Services, Trent University and Sir Sanford Fleming College, Peterborough, ON, Canada; 2Department of Psychiatry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada; 3University of Lethbridge Health Centre, Lethbridge, AB, Canada Abstract: A PubMed review was conduc